Synovial IL-6 was significantly higher in the patients with PJI (median, 34,477 ng/L; range, 295–50,000 ng/L; p<0.0001) than in those with aseptic failure (median, 565.0 ng/L; range, 7.0–24,839 ng/L). The gene discussed is IL6; the disease is juvenile polyposis syndrome.