Using a Venn diagram to visualize the up-regulated genes in the acne samples compared to healthy ones and in the TLR1/2- and TLR4-stimulated SZ95 sebocytes at 24 hours, a possible contribution of sebocytes with 92 of the 900 significantly altered transcripts in acne could be detected (Fig 3B). The gene discussed is TLR4; the disease is acne.