Moreover, as revealed by a number of genes (SERPINA3, TNFAIP6, C1R, SERPINE1, C3, THBD, PLAU, IRAK2, SOD2, PLSCR1, VNN1, SAA1, SAA2, PTX3, S100A9, S100A8, CFB, and IDO1), sebocytes via their products might also contribute to wound healing which is also a novel field yet to be characterized and could bring us closer to understand the background of acne-associated scarring. Here, C1R is linked to acne.