Compared to the moment before incision, CRS and 30 minutes chemotherapy resulted in a significant increase of WBC, glucose concentration, lactate, EXTEM CFT, INTEM CFT and FIBTEM CFT (p values of 0.001, <0.001, <0.001, < 0.001, 0.008 and 0.019, respectively) and a significant decrease in calcium concentration, pH, prothrombin time, fibrinogen (p values of 0.026, 0.011, 0.022 and <0.001, respectively). Here, F2 is linked to congenital rubella syndrome.