To examine expression and its clinical significance of ARNT/HIF‐1β in MM, we first analyzed the gene expression profile (GEP) dataset of patients enrolled in the Total Therapy (TT) trial (UAMS Multiple Myeloma Database, University of Arkansas).22, 24, 31 As shown in Figure 1A, there was no noticeable change in ARNT expression between normal donors (ND) and patients with asymptomatic monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM). Here, ARNT is linked to smoldering plasma cell myeloma.