In this context, cobalt (CoCl2), an approach widely used to mimic hypoxia, stabilizes HIF‐1α through inhibition of its hydroxylation mediated by PHDs and following degradation via UPS.50 However, cobalt failed to induce HIF‐1β expression in MM cells, suggesting that this HIF‐1α inducer might not be an optimal approach to mimic hypoxic microenvironment in MM. Here, ARNT is linked to Miyoshi myopathy.