EPAS1 and Miyoshi myopathy: MM microenvironment is featured by hypoxia that naturally exists in bone marrow niche where MM cells reside.48 Moreover, hypoxia is known to play an important role in MM cell survival and growth, disease progression, and drug resistance.49 Hypoxic responses are primarily mediated by the HIF family including HIF‐1α, HIF‐2α, HIF‐3α, and HIF‐1β.