In prostate cancer cells, V‐ATPase co‐localized with prostate specific antigen (PSA; a secreted tumor marker that is regulated by the androgen receptor [AR]) in the Golgi and V‐ATPase inhibition resulted in a relocalization of PSA to lysosome‐like intracellular vesicles.50 Interestingly, in androgen‐sensitive LNCaP prostate cancer cells, V‐ATPase inhibition also reduced PSA mRNA expression, suggesting upstream inhibition of AR's transcription activating activity.50 Here, KLK3 is linked to prostate cancer.