MMP9 and hepatocellular carcinoma: For example, in ovarian cancer cells, Voa2 was found to be localized in endosomes and inhibition showed a decrease in MMP‐9 and ‐2 activity.37 A study in hepatocellular carcinoma (HCC) found that inhibiting the Voc subunit led to decreased MMP‐2 expression and extracellular MMP‐2 activity.56