Interestingly, DUXAP8 has also been reported to be overexpressed in human non small cell lung cancer,24 gastric cancer25 and renal cell carcinoma,26 while LINC00460 expression is upregulated in nasopharyngeal carcinoma27 and promotes carcinogenesis in ESCC.28 Therefore, we chose these two lncRNAs for further analyses and validation. The gene discussed is LINC00460; the disease is esophageal squamous cell carcinoma.