In this study, we analyzed two upregulated lncRNAs DUXAP8 and LINC00460 co‐expressed PCGs in esophageal cancer, and found that DUXAP8 associated PCGs are enriched in cell division and cell cycle, while LINC00460 associated PCGs are enriched in focal adhesion and cell‐cell junction processes. Here, DUXAP8 is linked to esophageal cancer.