LARGE1 and Insulin resistance: Furthermore, homozygous LARGE1 rs16993330 carriers had increased insulin resistance, indicated by higher levels of fasting serum insulin (0.22 SD [95% CI 0.027, 0.41], p = 0.026) and HOMA-IR (0.24 SD [95% CI 0.048, 0.44], p = 0.014), and lower levels of the ISI (−0.21 SD [95% CI −0.016, −0.41], p = 0.034) (Table 2).