ITGA1 and type 2 diabetes mellitus: The novel variants in ITGA1 and LARGE1 had a high impact on risk of type 2 diabetes in Greenlanders, evident by the estimated effect sizes (Table 1) and by the higher frequency of type 2 diabetes among homozygous carriers compared with non-carriers (24.9% and 28.9% vs 10%; Fig. 2).