Interestingly, we identified NPY (enriched in PIN regions), SPON2 (enriched in cancer regions) and NR4A1 (enriched in reactive stroma, see below) also in patient 2 and 3 (Supplementary Fig. 15b), while EEF2, NEAT1, and TPT1 (established interaction with p53)32 were uniquely expressed in patient 3 (Supplementary Fig. 16). The gene discussed is SPON2; the disease is cancer.