HNRNPA2B1 and melanoma: On the other hand, in the case of melanoma cells, we observed that H1.0 present in EVs (but not that present in total cell lysates) is probably sumoylated, and sumoylation has been already reported as important for sorting to vesicles, for example, of alpha-synuclein [162], and hnRNPA2B1, as well as of hnRNPA2B1-bound microRNAs [163].