Cytokines such as IL-1β, TNF-α, or platelet-activating factor are most often directly connected with the progression of inflammation, whereas the co-occurring activity of cytokines, i.e., IL-6, IL-8, IL-10, or free radicals in the course of AP, can affect the extent of inflammation and be associated with AP prognosis [9,15,36]. Here, TNF is linked to alkaline phosphatase measurement.