Supplementary Figure S1a presents the profilers of these parameters with vegetable intake and the interaction profiles of the remaining parameters. The lines of association with CRC risk crossed and were non-parallel for overweight BMI status, with gender and BMI interacting with the MTHFR 677 polymorphism (see Supplementary Figure S1b) as gene-environment interactions. Here, MTHFR is linked to colorectal carcinoma.