Therefore, it is not surprising that Mps1 is upregulated in a wide range of human tumor types, and that higher levels correlate to higher histological grade, invasion, and poorer patient survival in hepatocellular carcinoma, breast cancer, glioblastoma, and colon cancer, as well as pancreatic ductal adenocarcinoma [5,6,7]. This evidence concerns the gene TTK and hepatocellular carcinoma.