Total immunoglobulin E (IgE) and ovalbumin (OVA)-specific IgE levels were diminished in an OVA-induced asthma model, and reductions in IL-4, IL-5 [56,130], TNF-α [132,133], and TGF-β1 [57] cytokine levels were found. The gene discussed is IGHE; the disease is asthma.