A growing body of evidence suggests that PGC-1α might be responsible for RPE oxidative metabolism and antioxidant defense, retinal light sensibility (Egger et al., 2012; Iacovelli et al., 2016), and the regulation of normal and pathological angiogenesis in the retina (Saint-Geniez et al., 2013); repressed activity of PGC-1α might contribute to AMD (Golestaneh et al., 2016). This evidence concerns the gene PPARGC1A and age-related macular degeneration.