When we directly compared the clinical, hormonal and metabolic parameters at 24 months in GHD children according to gender, females showed significantly higher BMI (P = 0.027), lower ISI (P < 0.001) and DIo (P < 0.001) and higher values of WC (P = 0.059), although not statistically significant (Table 2), while no significant difference was found in height, IGF-I, fasting glucose, fasting insulin, HbA1c, Homa-IR and lipids profile. Here, IGF1 is linked to HOMA-IR.