While AZD1775 exposure to KIL cells alone did appear to modestly blunt their ability to lyse MOC2 target cells, it had little impact on KIL expansion in the presence of IL-2 or viability and the net effect following exposure of both tumor and murine KIL or human haNK cells to AZD1775 was enhanced tumor cell susceptibility to NK killing. The gene discussed is IL2; the disease is neoplasm.