The series of multivariable adjusted analyses showed that lifestyle (diet and physical activity) and genetic factors (single nucleotide polymorphisms (SNP) previously associated with hepatic steatosis: SNPs LYPLAL1 (rs12137855); GCKR (rs780094); PPP1R3B (rs4240624); NCAN (rs2228603); PNPLA3 (rs738409); SREBP-1f (rs11868035)) had little impact on the associations (Additional File 1: Table S1). The gene discussed is PNPLA3; the disease is fatty liver disease.