Increased DNL is associated with increased size of VLDL particles, with Fabbrini et al. [27] making the intriguing observation that while apoB100 production is proportional to VLDL secretion and DNL production of FAs in the liver in individuals with normal hepatic fat content, apoB100 production does not keep pace with TAG VLDL secretion in fatty liver disease, first leading to increased VLDL particle size and then increased hepatic TAG deposition as export of de novo FAs is impaired. Here, APOB is linked to fatty liver disease.