In vitro studies of silencing APE1 using siRNA rendered ovarian cancer cell lines sensitive to cisplatin and resulted in cell apoptosis [70].Methoxyamine has been found to inhibit APE1 in other cancers and studies of methoxyamine in ovarian cancer cell lines have found it to increase sensitivity to alkylatortemozolmide [71, 72]. The gene discussed is APEX1; the disease is ovarian carcinoma.