In particular, cecal ligation and puncture (CLP) in mice, leading to polymicrobial sepsis, has demonstrated that proestrus female mice display a higher survival rate than male mice, along with a marked increase in splenocyte proliferation and IL-2/IL-3 release as compared with male mice, suggesting that immune homeostasis regulation is better regulated in females than in males [180]. This evidence concerns the gene IL2 and Sepsis.