It has been reported that mosaic mice with a heterozygous deficiency of the X-linked Nox2 gene (that encodes the catalytic subunit of the NADPH oxidase complex in phagocytes) displays a clear advantage during CLP as compared with wild-type animals, which is characterized by lower plasma IL-6 levels, reduced oxidative stress, higher bacterial clearance and improved survival, highlighting the contribution of genetic factors in the sexual dimorphism during sepsis [214]. The gene discussed is IL6; the disease is Sepsis.