It has been recently reported that raloxifene, a selective ER modulator, reduces the effects of LPS-induced endotoxemia in ovariectomized rats via the induction of antioxidant and anti-inflammatory proteins such as heme oxygenase 1 (HO-1) and heat shock protein 70 (HSP70), respectively [203]. The gene discussed is HMOX1; the disease is serum lipopolysaccharide activity.