In line with this, women show a higher pro-inflammatory innate immune response during experimental endotoxemia than men, as revealed by a higher leukocyte sequestration, greater levels of the pro-inflammatory cytokine TNF-α, and increased levels of the LBP without changes in the anti-inflammatory cytokine IL-10 [206]. The gene discussed is LBP; the disease is serum lipopolysaccharide activity.