UBASH3A and leukemia: Notably, the differential signaling networks of Bcr-Abl p210 and p190 kinases in leukemia cells have very recently been identified by functional proteomics, e.g., demonstrating a strong and preferential binding of AP2 complex, a major regulator of clathrin-mediated endocytosis, with p190, whereas Bcr-Abl is likely to be inhibited by p210-selective interactor Sts2 tyrosine phosphatase [68].