NLRP3 and B-cell chronic lymphocytic leukemia: In particular, the low levels of NLRP3 transcript in CLL patients may play a putative role in supporting leukemic cell growth, in line with data by Salaro et al. sustaining that NLRP3 interferes with CLL progression in virtue of its ability to modulate cytokine release and apoptosis, and thus controls inflammation [38].