We evaluated the transcriptional profiling of 84 genes involved in Innate and Adaptive Immune processes in isolated CD4+ T cells from HVs (n = 10) and CLL patients (n = 10) after in vitro stimulation with IL-6 o/n and PIM for 5 h (Additional file 2: Table S1). This evidence concerns the gene IL6 and B-cell chronic lymphocytic leukemia.