With regard to the down-regulation of important genes involved in T cell development and differentiation, e.g. CXCR3, IL-23A and RORC, we hypothesize a mechanism of negative regulation related to a sub-subset of TH17 known as TH17-23 which generates the effector cells involved in anti-tumor immunity [39]. The gene discussed is CXCR3; the disease is neoplasm.