Presently, poor clinicopathological characteristics (such as TNM classification, depth of tumor penetration, and lymph node metastasis) and high carcinoembryonic antigen (CEA) are predictive of high-risk post-operative tumor recurrence; but their use is limited due to low specificity and accuracy [4–7]. This evidence concerns the gene CEACAM5 and metastatic malignant neoplasm in the lymph nodes.