GCG and obesity due to melanocortin 4 receptor deficiency: Insulin resistance in peripheral adipocytes contributes to HT risk under obesity, which explains the association of lipid metabolism/signaling pathways with HT in Fig. 6d [Synthesis of (16–20)- hydroxyeicosatetraenoic acids (HETE), Glucagon signaling in metabolic regulation, and AMP-activated protein kinase inhibits carbohydrate response element binding protein (ChREBP) transcription activity] and that of the Glucagon-type ligand receptors pathway in Fig. 6e.