RBBP5 and colon adenocarcinoma: To evaluate the expression of the components of the WRAD subcomplex in cancer, the mRNA levels of WDR5, RBBP5, ASH2L, and DPY30 in tumors compared to normal solid tissue samples were examined based on RNASeq analysis from the colon adenocarcinoma (COAD) dataset within The Cancer Genome Atlas (Fig. 1a).