WDR5 is also overexpressed at the mRNA (Fig. 1b) and protein level (Fig. 1c) in a panel of colon cancer cells as compared to immortalized, yet non-transformed human colon epithelial cells (HCECs) [18] suggesting WDR5 may play a pro-tumorigenic role in colon cancer. Here, WDR5 is linked to colonic neoplasm.