We then examined the role of Drp1 in impaired wound healing in T2DM mice and found that gene transfer of Drp1-DN or Drp1-C644A in wounded tissues of db/db mice rescued impaired wound healing and angiogenesis (CD31+ capillary density) compared with LacZ (Figures 7F and 7G and S6E). This evidence concerns the gene PECAM1 and type 2 diabetes mellitus.