VWF and von Willebrand disease (hereditary or acquired): After sequencing VWF, it could be observed that only five out of 13 were carrying mutations previously described (S5 Table). Two of these patients presented the p.Arg1399His mutation classified as type 2M VWD [27], one other patient presented the p.Leu1382Pro mutation and the remaining two patients carried the p.Gly1415Asp mutation previously described as causing type 1 VWD [28] but considered in our project, in the light of phenotypic results, as type 2M VWD (S5 Table)(S5 Fig).