It is interesting to note that the depletion of FUK in WM793 melanoma cells at least partially abrogated the L-fucose-mediated inhibition of invadopodium formation, suggesting that the downregulation of FUK in metastatic melanoma might desensitize melanoma cells to the anti-metastatic effects of L-fucose. This evidence concerns the gene FCSK and metastatic melanoma.