FCSK and melanoma: The assembly and maturation of invadopodia are controlled by many glycosylated plasma membrane proteins such as integrins, growth factor receptors, ion channels/exchangers, matrix metalloproteases, etc. Our findings that the modulation of FUK and the fucose salvage pathway inhibits both the initiation of invadopodial assembly and the proteolytic activity of invadopodia establishes a foundation for future exploration of how the fucose salvage pathway regulates the functions of such crucial invadopodial proteins, and importantly, metastatic capacity in melanoma.