For instance, as reflected in the differing patterns within each gene (rows) in the heatmap, Aerococcus and Dorea both show higher abundances within tumors harboring LoF mutations in ZNF717, CTBP2, and APC, relative to tumors with LoF mutations in ANKRD36C and KMT2C. This highlights the different patterns in the microbiome that can be found when assessing genetically heterogeneous sets of tumors, as Dorea has been found to be differentially present in tumor microbiomes by several different groups. The gene discussed is APC; the disease is neoplasm.