We found that we are able to use microbiome composition profiles to predict the existence of tumor LoF mutations in the human genes APC, ANKRD36C, CTBP2, KMT2C, and ZNF717 (Q-value = 0.0011, 0.0011, 0.019, 0.019, and 0.055, respectively, by permutation test after False Discovery Rate (FDR) correction for multiple tests; Fig 2). The gene discussed is APC; the disease is neoplasm.