Recent studies showed that the direct effect of GLP-1 on hepatocytes from humansubjects with non-alcoholic steatohepatitis could be mediated by activating genesinvolved in insulin sensitivity and fatty acid oxidation, while weight loss coulddecrease hepatic steatosis while increasing insulin sensitivity (21,22).Wang and coworkers also reported that exenatide reduces hepatic cells andmitochondrial structural anomaly and improves insulin resistance in concert withimprovements in insulin sensitivity and mitochondrial function activation,concomitantly with reductions in oxidative stress (23). The gene discussed is GLP1R; the disease is Insulin resistance.