MUC5AC and neoplasm: The development of chordoma in men is more than in women (ratio 2: 1), and lesions typically arise in the sacrococcygeal area (29–57%), clivus area (27–35%), and vertebrae (10–33%).[18] In the spinal columns, the tumor is located in the cervical spine (15–52%), lumbar spine (33–35%), and thoracic spine (14–17%).[15] Histological examination described that these tumor cells often are separated by variable amounts of intercellular mucin and contain numerous intracytoplasmic vacuoles, accounting for 1% to 4% of all bone neoplasms.[1]