Clinical study has found that the 5-year recurrence and metastasis rate is significantly lower in the TCM treatment group than that in the simple Western control group.[13] In addition, a high dose of TCM Decoction has a similar killing effect on MDA-MB-435 compared with cyclophosphamide; meanwhile, TCM Decoction can reduce the expression of vascular endothelial growth factor (VEGF) and its receptors FlK-1 in BC tumor tissue, indicating that TCM has an important role in anti-tumor and anti-metastasis effects.[14]. Here, VEGFA is linked to breast cancer.