EMT is a biologic process by which epithelial cells lose their polarity and gain migratory and invasive properties to transition into a mesenchymal phenotype.31 EMT has been determined to be essential for numerous developmental processes, and increasing evidence reveals that EMT also occurs in the initiation of tumor cells metastasis during cancer progression.32 These findings suggest that LINC00704 might play a critical role in thyroid cancer tumorigenesis and progression, which partly depends on regulation of cell EMT. The gene discussed is MANCR; the disease is cancer.