S1PR1 and cancer: However, while FTY720 phosphorylated by SPHK2 to form FTY720‐phosphate (FTY720‐p) was suggested to a functional antagonist of S1PR1 through binding to S1PR1 and induces internalization and degradation, leading to sequestration of thymocytes and lymphocytes from secondary lymphoid organs thereby reducing inflammation.2, 5, 50, 51 FTY720 demonstrates anti‐cancer properties and may have a potential in cancer treatment.52, 53 There are many in vitro and in vivo studies demonstrated the growth arrest and apoptosis‐inducing ability of FTY720.