S1PR1 and ischemia reperfusion injury: It has been demonstrated to regulate both T and B cells and improve the outcome of atherosclerosis disease.55 SEW2871 is also a selective S1PR1 agonist and has been used to treat acute kidney injury and ischemia‐reperfusion injury in mice.56, 57 SEW2871 binds to S1PR1 causing its internalization and recycling.