Studies found that corilagin may control cholangiocarcinoma cell growth by down‐regulating the expression of Notch1,36 arrests SMMC7721 cells at the G2/M phase by down‐regulating p‐Akt and cyclinB1/cdc2 and up‐regulating p‐p53 and p21Cip1.8 However, few reports examined the concrete mechanism in corilagin mediating cell death. The gene discussed is CDKN1A; the disease is cholangiocarcinoma.