RIPK3 and cancer: Recently, programmed necrosis, namely necroptosis, is found as a new kind of programmed cell death in cancer cell death which was resulted by anticancer agents.32 Receptor‐interacting protein kinase‐3 (RIP3 or RIPK3) is an essential part of the cellular machinery that executes the programmed necrotic cell death.52, 53, 54 In our study, we utilized SK‐BR3 cells which express high level of RIP3 to confirm whether necroptosis can be induced by corilagin.