NUDT15 and Decreased total leukocyte count: As previously reported, we confirmed the strong associations of NUDT15 p.Arg139Cys with leukopenia and alopecia (p = 2.20E−63 and 1.32E−69, OR = 6.59 and 12.1, respectively), and we newly identified its significant association with thiopurine-induced digestive symptoms (p = 6.39E−04, OR = 1.89) (Table 1).