However, we confirmed the association of digestive symptoms even after excluding all leukopenia cases [6.8% in Arg/Arg and 14.0% in Arg/Cys, p = 6.20E−03, OR = 2.22 (1.28–3.86)]; this may be one line of evidence, suggesting that NUDT15 variants are directly associated with digestive symptoms. Here, NUDT15 is linked to Decreased total leukocyte count.