Curcumin was found to inhibit EGF-induced upregulation of AQP3 and migration in human ovarian cancer cells, via inhibition of AKT/ERK and PI3K pathways (Ji et al., 2008); however, curcumin affects a number of biochemical pathways and might not be suited when AQP-specific modulation is required (Aggarwal et al., 2003). This evidence concerns the gene EGF and ovarian cancer.