Similarly, AQP1 gene deletion correlated with reduced VEGF receptor expression in mouse primary breast tumor cells (Esteva-Font et al., 2014), and knockdown of AQP1 in human retinal vascular endothelial cells with concurrent inhibition of VEGF caused an additive inhibition of hypoxia-induced angiogenesis (Kaneko et al., 2008). Here, AQP1 is linked to breast neoplasm.