Given the diverse array of functional properties, mechanisms of regulation, and tissue-specific distributions being discovered for aquaporins, it is not surprising that different classes of aquaporins (AQP-1,−2,−3,−4,−5,−8, and−9) have been implicated specifically in the complex steps associated with cancer invasion and metastasis (Table 1), suggesting specialized roles for these channels have been arrogated into the pathological processes. The gene discussed is AQP1; the disease is cancer.