PTK2 and neoplasm: •Upregulated in response to tumor tissue hypoxia. Enables recruitment of new tumor vasculature by enhancing endothelial cell migration •Polarizes to leading and trailing edge of migrating cell, and enhances tumor cell migration and invasion by enabling rapid membrane protrusion formation via cell volume regulation and interaction with cytoskeletal dynamics •Enhances mesenchymal stem cell migration via FAK and β-catenin pathways •Might contribute to EMT •Possible interaction with ECM-degrading proteases