However, application of VEGF-neutralizing antibodies did not alter AQP1 expression (Kaneko et al., 2008), and levels of VEGF in primary breast tumors were not different between AQP1-null and wild-type mice (Esteva-Font et al., 2014), supporting the idea that VEGF is regulated independently of AQP1 expression or activity. Here, AQP1 is linked to breast neoplasm.