Metabolic enzyme mutations are common in various cancers, for example, mutations in succinate dehydrogenase (SDH) are present in paragangliomas, gastrointestinal stromal tumors, neuroblastomas, renal tumors, and thyroid carcinomas (Bardella, Pollard & Tomlinson, 2011), isocitrate dehydrogenase (IDH) mutations are in many central nervous system cancers, leukemia, prostate cancer, and colon cancer (Yen et al., 2010), and fumarate hydratase (FH) mutations are found in fibroids, skin, and renal cancers (Tomlinson et al., 2002; Toro et al., 2003) among others. The gene discussed is FH; the disease is central nervous system cancer.