For example, P53 is a transcription factor that is responsible for expressing target genes that inhibit the cell cycle and induce apoptosis; however, studies have shown that this transcription factor is one of the most commonly mutated in cancers (Sionov & Haupt, 1999; Ozaki & Nakagawara, 2011; Vogiatzi et al., 2016). Here, TP53 is linked to cancer.