In this study, out of 107 samples that for HBV viral load were positive; 64.7% of them had HBVDNA levels< 2000 IU/ml and they were in chronic hepatitis B immune control phase or inactive Hepatitis B levels; also HBV-DNA levels in about 35.3% of HBeAb positive samples was > 2000 IU/ml and they were in HBeAg negative chronic hepatitis B phase or the immune active phase that only in 9.7% of HBe-Ab positive samples, mutation of pre core and core regions was detected. The gene discussed is HBE1; the disease is chronic hepatitis B virus infection.