Methamphetamine (MA) produces significant alterations in factors that mediate apoptosis, thrombosis, and atherosclerosis, such as B-cell lymphoma 2 (Bcl-2) (Cadet et al., 1997; Imam et al., 2001; Deng et al., 2002; Dluzen et al., 2011) and plasminogen activator inhibitor-1 in male mice (Dluzen et al., 2003), in the case of Bcl-2, downregulation and upregulation of expression after methamphetamine doses is dependent of the timing when measurement is done. This evidence concerns the gene BCL2 and atherosclerosis.