Furthermore, the frequency of TNFR2+ Tregs in PB CD4+ T cells from ND AML patients (9.65 ± 3.99%) was also significantly higher than that in healthy controls (3.22 ± 1.4%, P < 0.01) and CR patients (1.01 ± 0.25%, P < 0.01) (Figure 5C). Here, CD4 is linked to acute myeloid leukemia.