In our study, CD4+CD25high T cells expressed higher proportion of TNFR2 when compared with CD4+CD25+ Tregs in healthy controls (63.27 ± 13.31 vs 41.48 ± 13%, P < 0.01) and ND AML patients (87.11 ± 3.35 vs 70.09 ± 16.57%, P < 0.01) as well as CR patients (43.45 ± 6.05 vs 32.81 ± 18.01%, P < 0.01) (Figure 5D). The gene discussed is TNFRSF1B; the disease is acute myeloid leukemia.