Inhibition of IL-17 receptor A by antibody neutralization worsened disease in the multidrug resistance-1a-ablated (Abcb1a−/−) murine model of colitis and was associated with increased epithelial permeability as detected by increased serum concentrations of soluble CD14 and LPS binding protein and increased plasma concentrations of orally administered sucralose, lactulose, and mannitol (70). This evidence concerns the gene IL17RA and colitis.