PML and cytomegalovirus infection: For example, PML-NB constituents may be degraded following HSV-1 and human cytomegalovirus (HCMV) infections, which resulted in the disruption of PML-NBs (7, 9), whereas PML-NB deformation and reorganization were observed in adenovirus and papillomavirus infections, respectively (10, 11); and (III) PML KO mice were prone to infections (12).