In KRasG12D-driven lung cancer mouse model, it has been reported that ablation of Atg5 favors adenosinergic signaling via a HIF-1α pathway, as well as the infiltration of tumors by Tregs, thus influencing inflammatory and immunosurveillance mechanisms that can stimulate and control carcinogenesis, respectively (96). Here, ATG5 is linked to lung carcinoma.