In the context of naive T cells, it has been reported that tumor-derived metabolite lactate selectively inhibits FAK family–interacting protein of 200 kDa (FIP200; also known as RB1CC1) in naive T cell leading to autophagy deficiency, apoptosis and poor anti-tumor immunity in ovarian cancer patients, and tumor-bearing mice (93). Here, PROS1 is linked to neoplasm.