Systemic IL-23 overexpression induced local inflammation in the enthesis by triggering resident IL-23R+RORγt+CD3+CD4−CD8− lymphocytes to secrete IL-17 and IL-22, ultimately leading to IL-17-dependent enthesitis, IL-22-dependent bone remodeling as well as aortic root inflammation and psoriasis (64). The gene discussed is IL22; the disease is psoriasis.