The results showed that multiple differentially regulated proteins were enriched in several receptor-ligand interaction pathways (such as “ECM-receptor interaction” and “cytokine-cytokine receptor interaction”) and signaling pathways (such as the “PI3K-AKT signaling pathway” and the “p53 signaling pathway”), indicating that some members of these pathways are significantly affected by ZIKV infection. Here, AKT1 is linked to Zika virus infectious disease.