The aim of the current study is to investigate possible relationship between neuroendocrine disorders and etio-pathology of vitiligo by evaluating plasma and serum levels of norepinephrine (NE), epinephrine (Epi), dopamine (DA), homo-vanillic acid (HVA), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), melatonin, free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulation hormone (TSH), estradiol, testosterone, prolactin, cortisol, and ACTH in blood samples of active and stable vitiligo subjects in a comparative study with healthy subjects. This evidence concerns the gene POMC and vitiligo.