NGB and intracerebral hemorrhage: Overexpression of Ngb reduced the extent of brain injury as elicited by experimentally-induced intracerebral hemorrhage (38), while exogenous Ngb protein administration (via treatment with Ngb that was fused to the 11-amino-acid human immunodeficiency virus transactivator of transcription protein transduction domain) not only efficiently transduced into neurons in the mouse brain, but also afforded significant protection to the brain from mild or even moderate ischemic injury (39).