Considering the complexity of BNP system and the heterogeneity of HF status, not only the processing of proBNP (corin/furin) and BNP (neprilysin), but also the effects of glycosylation on proBNP processing and BNP assays, should be targeted in future studies to enhance their diagnostic, therapeutic and prognostic values. This evidence concerns the gene CORIN and hydrops fetalis.