RASA3 and Bone marrow hypocellularity: Though existing data is intriguing and suggestive of galectin-1’s importance, future studies will be required to prove any mechanistic role for galectin-1 in the cyclic bone marrow failure phenotype, rather than its decrease simply being an effect of loss of RASA3 function across all cell types in the mouse, or a generic serum biomarker of disease.