TGFB1 and neoplasm: Tumor-derived EVs directly participate in immune evasion, for example by generation of suppressive myeloid cells (Valenti et al., 2006), by expressing FasL and inducing T cell death (Andreola et al., 2002; Kim et al., 2005), as well as other suppressive molecules, such as PD-L1, TRAIL, IL-10, and TGF-β, which induce regulatory T cells (Tregs).