Functional plasma membrane multidrug efflux transporters, such as P-glycoprotein (P-gp) or Multidrug Resistance-Associated Protein 1 (MRP-1), can be shed from resistant cancer cells as cargo of membrane microvesicles and transferred to drug-sensitive recipient cells (Bebawy et al., 2009; Lu et al., 2013). The gene discussed is ABCC1; the disease is cancer.